【解答】Biosafety and other considerations for research with viruses

rodiyer.idv.tw 拉里拉雜

問	What are the criteria for classifying viruses into different risk groups?
	Whether new variants frequently emerge
✓	Whether it affects human health
✓	Severity of the corresponding infectious disease
	Transmissibility
✓	Availability of effective therapeutic or preventive measures
	www.rodiyer.com
問	Monitoring viruses emerging in nature does not constitute gain-of-function (GOF) research; however, if a potentially high-risk viral strain is detected, it should be reported to the regulatory authori...(以下略)
✓	〇
	╳
	www.rodiyer.com
問	Viruses with new characteristics generated through serial passaging of a virus are not necessarily all gain-of-function (GOF).
✓	〇
	╳
	www.rodiyer.com
問	Performing infection experiments in a BSL-3 laboratory is almost the same as in a BSL-2 laboratory, except for wearing additional personal protective equipment.
	〇
✓	╳
	www.rodiyer.com
問	Even though I have experience handling Risk Group 2 (RG-2) viruses, I must still undergo prior assessment, training, and evaluation to obtain operational qualifications if I want to perform experiment...(以下略)
✓	〇
	╳
	www.rodiyer.com
問	Performing infection experiments inside a biosafety cabinet is primarily to ensure that the cells used in my experiment do not get contaminated.
	〇
✓	╳
	www.rodiyer.com
問	The experimental methods and workflows I use for Risk Group 2 (RG-2) viruses in a BSL-2 laboratory can be identically applied to Risk Group 3 (RG-3) viruses in a BSL-3 laboratory.
	〇
✓	╳
	www.rodiyer.com
問	Since we don't know the outcome, experiments involving viral modification can be performed first, and a biosafety permit can be applied for after the results show that the modified virus has gained fu...(以下略)
	〇
✓	╳
	www.rodiyer.com
問	Which of the following can be considered methodologies for viral gain-of-function (GOF) research that require enhanced assessment during biosafety applications?
✓	Generation of chimeric viruses
	Removal of specific viral genes
✓	Site-directed modification of the viral genome
	Application of inhibitory drugs in a single-round infection experiment
✓	Serial passaging of the virus under inhibitory drug treatment of infected cells
	www.rodiyer.com
問	Which of the following is not an appropriate justification for performing viral functional modification experiments?
	To understanding the function of viral genes
✓	To prove that the research group is capable of modifying viruses
	To develop new antiviral drugs
✓	To enhance the impact of research results
	To investigate the transmission mechanisms of the virus

rodiyer.idv.tw 拉里拉雜